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Adenovirus-mediated GDNF protects cultured motoneurons from glutamate injury
2001
NeuroReport
The protective effects of adenovirus-mediated glia cell linederived neurotrophic factor (GDNF) gene transaction was investigated on cultured motoneurons. First, the dose± and time±response relationship of glutamate neurotoxicity was determined on spinal motoneuron cultures. Then, the effect of the gdnf recombinant adenovirus (AdCMVgdnf) was tested in this cellular model. AdCMVgdnf at 20 MOI (multiplicity of infection) was found to signi®cantly reduce the cell loss of motoneurons, as compared to
doi:10.1097/00001756-200110080-00018
pmid:11568639
fatcat:idnabuhofvattiskcwymoanhwa