Arterial compliance in patients with cirrhosis: stroke volume-pulse pressure ratio as simplified index

Jens H. Henriksen, Stefan Fuglsang, Flemming Bendtsen, Erik Christensen, Søren Møller
2001 American Journal of Physiology - Gastrointestinal and Liver Physiology  
Arterial compliance in patients with cirrhosis: stroke volume-pulse pressure ratio as simplified index. Am J Physiol Gastrointest Liver Physiol 280: G584-G594, 2001.-Arterial function may be altered in patients with cirrhosis. We determined compliance of the arterial tree (C 1 ) in relation to systemic and splanchnic hemodynamic derangement and clinical variables. C 1 and the stroke volume-pulse pressure index (SV/ PP) were significantly higher (ϩ62% and ϩ40%, respectively; P Ͻ 0.001) in
more » ... ic patients (n ϭ 49) than in control subjects (n ϭ 19), and a close correlation between C 1 and SV/PP was found in both cirrhotic patients (r ϭ 0.86, P Ͻ 0.001) and control subjects (r ϭ 0.96, P Ͻ 0.001). Univariate analysis showed significant relations between C 1 and SV/PP on one side and age, sex, body weight, portal pressure, systemic hemodynamics, biochemical variables, and severity of disease on the other. In the multiple-regression analysis, sex, age, mean arterial blood pressure, systemic vascular resistance, and biochemical variables were significant independent predictors of SV/PP (P Ͻ 0.005-0.00001). In conclusion, arterial compliance is elevated in cirrhosis. A simplified SV/PP index seems to reflect abnormalities in the arterial compliance of these patients. cardiac output; circulatory regulation; hyperdynamic circulation.
doi:10.1152/ajpgi.2001.280.4.g584 pmid:11254484 fatcat:jb2oc5u6drac7dmpbno7pgexaq