Pyrogenic Specificity of Streptococcal Exotoxins, Staphylococcal Enterotoxin, and Gram-Negative Endotoxin

K. W. Brunson, Dennis W. Watson
1974 Infection and Immunity  
Streptococcal exotoxin and staphylococcal enterotoxin share several biological properties, including pyrogenicity, lymphocyte mitogenicity, and enhancement of gram-negative endotoxin lethality. These analogies of the toxins prompted comparative pyrogenic studies. When American Dutch rabbits were immunized by repeated intravenous injections of small amounts of staphylococcal enterotoxin, they exhibited a decreased febrile response upon challenge when compared with control animals not previously
more » ... als not previously injected. The same animals responded similarly to control groups when challenged with streptococcal exotoxin A, B, or C. No cross-reactivity was observed in reciprocal cross-tests, using animals immune to the streptococcal toxins and challenging with staphylococcal enterotoxin. No cross-reactivity between either the streptococcal or staphylococcal toxins and bacterial endotoxin was observed. on May 9, 2020 by guest
doi:10.1128/iai.10.2.347-351.1974 fatcat:zdavr5krrnhlng2ozqfxpdez6e