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In vivo evidence of microstructural hypo-connectivity of brain white matter in 22q11.2 deletion syndrome
[post]
2020
unpublished
22q11.2 Deletion Syndrome, or 22q11.2DS, is a genetic syndrome associated with high rates of schizophrenia, autism, and attention deficit hyperactivity disorder, in addition to widespread structural and functional abnormalities throughout the brain. Experimental animal models have identified neuronal connectivity deficits, e.g., decreased axonal length and complexity of axonal branching, as a primary mechanism underlying atypical brain development in 22q11.2DS. However, it is still unclear
doi:10.21203/rs.3.rs-80221/v1
fatcat:xsyz7prlsfa2nh25juyc6sjuou