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MAdCAM-1/α4β7 Integrin-Mediated Lymphocyte/Endothelium Interactions Exacerbate Acute Immune-Mediated Hepatitis in Mice
Mucosal addressin cell-adhesion molecule-1 (MAdCAM-1)deficient mice show decreased susceptibility to concanavalin A (ConA)-induced hepatitis. ConA causes reduced motility and increased adhesion of lymphocytes in liver sinusoids, which depends on MAdCAM-1. b7 integrin expression contributes to MAdCAM-1 upregulation and liver damage. BACKGROUND & AIMS: Aberrant lymphocyte homing could potentially link inflammatory processes in the intestine and the liver, as distinct hepatobiliary diseasesdoi:10.18154/rwth-2020-12305 fatcat:p4l46h6aefacxbepk4l62lhxw4