MAdCAM-1/α4β7 Integrin-Mediated Lymphocyte/Endothelium Interactions Exacerbate Acute Immune-Mediated Hepatitis in Mice

Angela Schippers, Jessica Hübel, Felix Heymann, Thomas Clahsen, Sreepradha Eswaran, Sarah Schlepütz, Robin Püllen, Nikolaus Gaßler, Klaus Tenbrock, Frank Tacke, Norbert Wagner
Mucosal addressin cell-adhesion molecule-1 (MAdCAM-1)deficient mice show decreased susceptibility to concanavalin A (ConA)-induced hepatitis. ConA causes reduced motility and increased adhesion of lymphocytes in liver sinusoids, which depends on MAdCAM-1. b7 integrin expression contributes to MAdCAM-1 upregulation and liver damage. BACKGROUND & AIMS: Aberrant lymphocyte homing could potentially link inflammatory processes in the intestine and the liver, as distinct hepatobiliary diseases
more » ... tly develop as extra-intestinal manifestations in inflammatory bowel disease. In this study, we examined the role of the gut-tropic leukocyte adhesion molecule b7 integrin and its endothelial ligand mucosal addressin cell-adhesion molecule-1 (MAdCAM-1) in immune-mediated hepatitis in mice.
doi:10.18154/rwth-2020-12305 fatcat:p4l46h6aefacxbepk4l62lhxw4