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Targeted Macromolecules Delivery by Large Lipidic Nanovesicles Electrofusion with Mammalian Cells
Journal of Biomaterials and Nanobiotechnology
Lipidic nanovesicles (so called liposomes) were one the earliest forms of nanovectors. One of their limits was our lack of knowledge on the delivery pathway of their content to the target cell cytoplasm. The present communication describes an efficient way to enhance the delivery. Pulsed electric fields (PEF) are known since the early 80's to mediate a fusogenic state of plasma membranes when applied to a cell suspension or a tissue. Polykaryons are detected when PEF are applied on cells indoi:10.4236/jbnb.2011.225063 fatcat:brzhmzozwvdbxj43c6y2l6v57y