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We show here that expression of genes from convergent transcription units can be regulated by the formation of doublestranded RNA (dsRNA) in the region of overlapping polyadenylation signals. The model system employed is the mouse polyomavirus. The early and late genes of polyomavirus are transcribed from opposite strands of the circular viral genome. At early times after infection, the early genes are expressed predominantly. Late gene expression increases dramatically upon the onset of DNAdoi:10.1261/rna.1608909 pmid:19390116 pmcid:PMC2685520 fatcat:rux5ydcaafaaxjq2g6xfe5rcxm