Grip strength is a measure of overall strength that predicts adverse outcomes in old age. Grip strength trajectories throughout adulthood and their predictors are not well understood. We modeled growth trajectories of grip strength from Fels participants aged 18-60. Data from 403 participants (55% female) aged 29.4+6.6 years with subsequent visits through age sixty were included. We modeled latent grip strength groups, with predictors including demographic, health, behavioral, and biomarker

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... ables. Multiple, differing trajectory groups were observed in men and women. In initial models, 16% and 12% of men and women, respectively, had persistent poor grip strength throughout adulthood. A high grip strength group was identified in men and women that peaked in the sixth decade and associated with higher BMI in women and non-smoking in men. Group grip strength trajectories were evident, and membership predictors differed between sexes. Additional biomarker and health predictor group membership models will be discussed.