Studies conducted in 28 frequently ill children and 71 children with tuberous sclerosis, by applying the energy-intensive technique (a process of ligand-dependent redistribution of immunoglobulin receptors in В lymphocytes), have shown that the body's bioenergy deficiency is detected in different conditions; it may be transient and also a sequel of inherited mutations. Its degree and qualitative differences depend on many causes, in particular on disease pathogenesis, patient age, etc.