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Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells
Crotamine is a highly cationic; cysteine rich, cross-linked, low molecular mass cell penetrating peptide (CPP) from the venom of the South American rattlesnake. Potential application of crotamine in biomedicine may require its large-scale purification. To overcome difficulties related with the purification of natural crotamine (nCrot) we aimed in the present study to synthesize and characterize a crotamine analog (sCrot) as well investigate its CPP activity. Mass spectrometry analysisdoi:10.3390/molecules23040968 pmid:29693555 fatcat:337wenvrxvdljdsyyuchvgtvvq