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Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation
2015
Pharmacogenomics (London)
Aim: Studying the possible influence of SNPs on efficacy and safety of calcineurin inhibitors upon heart transplantation. Materials & methods: In 60 heart transplant patients treated with tacrolimus or cyclosporine, we studied a panel of 36 SNPs correlated with a series of clinical parameters during the first post-transplantation year. Results: The presence of serious infections was correlated to ABCB1 rs1128503 (p = 0.012), CC genotype reduced the probability of infections being also
doi:10.2217/pgs.15.39
pmid:26107754
fatcat:e7a7bsdcl5dpphah3uyvfylyva