Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation

Ignacio Sánchez-Lázaro, María José Herrero, Consuelo Jordán-De Luna, Virginia Bosó, Luis Almenar, Luis Rojas, Luis Martínez-Dolz, Juan E Megías-Vericat, Luis Sendra, Antonio Miguel, José L Poveda, Salvador F Aliño
2015 Pharmacogenomics (London)  
Aim: Studying the possible influence of SNPs on efficacy and safety of calcineurin inhibitors upon heart transplantation. Materials & methods: In 60 heart transplant patients treated with tacrolimus or cyclosporine, we studied a panel of 36 SNPs correlated with a series of clinical parameters during the first post-transplantation year. Results: The presence of serious infections was correlated to ABCB1 rs1128503 (p = 0.012), CC genotype reduced the probability of infections being also
more » ... with lower blood cyclosporine concentrations. Lower renal function levels were found in patients with rs9282564 AG (p = 0.003), related to higher blood cyclosporine blood levels. A tendency toward increased graft rejection (p = 0.05) was correlated to rs2066844 CC in NOD2/CARD15, a gene related to lymphocyte activation. Conclusion: Pharmacogenetics can help identify patients at increased risk of clinical complications.
doi:10.2217/pgs.15.39 pmid:26107754 fatcat:e7a7bsdcl5dpphah3uyvfylyva