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Hormone Interactions to Leu-rich Repeats in the Gonadotropin Receptors
Journal of Biological Chemistry
Human chorionic gonadotropin (hCG) binds to the extracellular N-terminal domain, exodomain, of its receptor, and the resulting hCG-exodomain complex is thought to modulate the membrane associated domain, endodomain, of the receptor to generate hormone signal. The bulk of the exodomain is speculated to assume a crescent structure consisting of eight to nine Leu-rich repeats (LRRs), which may provide the hormone contact sites. Unfortunately, little experimental evidence is available for thedoi:10.1074/jbc.m003774200 pmid:10880517 fatcat:su3gtjtt4jemjnv26d4aj2r5qq