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Although the cause of Alzheimer's disease (AD) remains unknown, a number of new findings suggest that the immune system may play a critical role in the early stages of the disease. Genome-wide association studies have identified a wide array of risk-associated genes for AD, many of which are associated with abnormal functioning of immune cells. Microglia are the brain's immune cells. They play an important role in maintaining the brain's extracellular environment, including clearance ofdoi:10.3233/jad-151075 pmid:26890782 pmcid:PMC4927862 fatcat:4qmgv7ahlnf7zaxsymbcw5yype