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Computational Methodologies for Real-Space Structural Refinement of Large Macromolecular Complexes
2016
Annual Review of Biophysics
The rise of the computer as a powerful tool for model building and refinement has revolutionized the field of structure determination for large biomolecular systems. Despite the wide availability of robust experimental methods capable of resolving structural details across a range of spatiotemporal resolutions, computational hybrid methods have the unique ability to integrate the diverse data from multimodal techniques such as X-ray crystallography and electron microscopy into consistent, fully
doi:10.1146/annurev-biophys-062215-011113
pmid:27145875
pmcid:PMC5526348
fatcat:rrcwq75t7rc6jbyg5etr44mzbe