Temporal metastates are associated with differential patterns of time-resolved connectivity, network topology, and attention

James M. Shine, Oluwasanmi Koyejo, Russell A. Poldrack
2016 Proceedings of the National Academy of Sciences of the United States of America  
Little is currently known about the coordination of neural activity over longitudinal time-scales and how these changes relate to behavior. To investigate this issue, we used resting-state fMRI data from a single individual to identify the presence of two distinct temporal states that fluctuated over the course of 18 months. We then demonstrated that these temporal states were associated with distinct neural dynamics within individual scanning sessions. In addition, the temporal states were
more » ... related to significant alterations in global efficiency, as well as differences in self-reported attention. These patterns were replicated in a separate longitudinal dataset, providing further supportive evidence for the presence of fluctuations in functional network topology over time. Together, our results underscore the importance of longitudinal phenotyping in cognitive neuroscience.
doi:10.1073/pnas.1604898113 pmid:27528672 pmcid:PMC5024627 fatcat:k6xj3u4rgbggbljtftxphg237m