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Human immunodeficiency virus infection and syncytium formation in HeLa cells expressing glycophospholipid-anchored CD4
Journal of Virology
The CD4 molecule, a glycoprotein expressed primarily on the cell surface of specific T lymphocytes, is thought to function in T-cell antigen recognition and activation. In addition, CD4 serves as a receptor for human immunodeficiency virus type 1 (HIV-1) by a direct interaction with the HIV-1 surface glycoprotein (gpl20). To further characterize the HIV-1-cell interaction, a HeLa cell line was established that expressed a chimeric molecule of CD4 and decay-accelerating factor (DAF). In thedoi:10.1128/jvi.65.6.3276-3283.1991 fatcat:kk2h5rvgpbhctnbmbblfu65pdu