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Lecture Notes in Computer Science
The gene family-free framework for comparative genomics aims at providing methods for gene order analysis that do not require prior gene family assignment, but work directly on a sequence similarity graph. We study two problems related to the breakpoint median of three genomes, which asks for the construction of a fourth genome that minimizes the sum of breakpoint distances to the input genomes. Methods: We present a model for constructing a median of three genomes in this family-free setting,doi:10.1007/978-3-319-43681-4_9 fatcat:qifvnbkwvrf4ldvu3ij3gfhspa