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Objective To assess changes in skin stiffness in SSc patients using SWE during a five-year follow-up. Methods Skin stiffness [i.e. shear-wave velocity values (SWV) in m/s] was assessed by SWE ultrasound (using virtual touch image quantification) at the 17 sites of the mRSS, in each participant, at baseline and follow-up. mRSS was performed at both time points. Differences between groups were analysed using the related-samples Wilcoxon Signed Rank test and the Mann-Whitney U test. Results Wedoi:10.21203/rs.2.18735/v2 fatcat:6dntbvjo5vhuphqhfi33dtzpiq