Manual therapy has long been a component of physical rehabilitation programs, especially to treat those in pain. The mechanisms of manual therapy, however, are not fully understood, and it has been suggested that its pain modulatory effects are of neurophysiological origin, and may be mediated by the descending modulatory circuit. Therefore, the purpose of this review is to examine the neurophysiological response of different types of manual therapy, in order to better understand the

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... logical mechanisms behind each therapy's analgesic effects. It is concluded that different forms of manual therapy elicit analgesic effects via different mechanisms. Additionally, future avenues of mechanistic research pertaining to manual therapy are discussed.