Understanding how economies change through the interactions with science and governance as different spheres of activity, requires either new conceptual tools or advances in existing ones. In this paper the evolution of the metaphor of a Triple Helix of university-industry-government relations is positioned within the context of global economic change, highlighting how these relations are both continuing and mutating or changing, and the conditions under which a Triple Helix might be seen to be

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... unraveling in the face of pressures on each of the three helicesuniversity-industry-government. The reciprocal dynamics of innovation both in the Triple Helix thesis and in the global economy are systemically explored.