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Thrombospondin Plays a Vital Role in the Immune Privilege of the Eye
Investigative Ophthalmology and Visual Science
PURPOSE. The role of thrombospondin (TSP)-1 in TGF-␤ activation and T-cell suppression was studied in the retinal pigment epithelial (RPE) cells, a monolayer of pigmented cells that line the subretinal space, an immune-privileged site in the eye. METHODS. Posterior eyecups were prepared by excising the anterior segment, lens, and retina from enucleated eyes of C57BL/6, thrombospondin-1 knockout (TSP-1KO), and TGF-␤2 receptor II double-negative (TGF-␤2 RII DN) mice, leaving behind a healthydoi:10.1167/iovs.04-0362 pmid:15728547 fatcat:pzdjqt7ytbfnbn4nedmbsqhgra