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Adjunctive α2-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission
International Journal of Neuropsychopharmacology
Compared to both first-and second-generation antipsychotic drugs (APDs), clozapine shows superior efficacy in treatment-resistant schizophrenia. In contrast to most APDs clozapine possesses high affinity for a 2 -adrenoceptors, and clinical and preclinical studies provide evidence that the a 2 -adrenoceptor antagonist idazoxan enhances the antipsychotic efficacy of typical D 2 receptor antagonists as well as olanzapine. Risperidone has lower affinity for a 2 -adrenoceptors than clozapine butdoi:10.1017/s1461145709990794 pmid:19835668 fatcat:u2oqvccw2bdfdaikw6dknjwjxe