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Personalized medicine for mucositis: Bayesian networks identify unique gene clusters which predict the response to gamma-d-glutamyl-l-tryptophan (SCV-07) for the attenuation of chemoradiation-induced oral mucositis
2011
Oral Oncology
s u m m a r y Gamma-D-glutamyl-L-tryptophan (SCV-07) demonstrated an overall efficacy signal in ameliorating oral mucositis (OM) in a clinical trial of head and neck cancer patients. However, not all SCV-07-treated subjects responded positively. Here we determined if specific gene clusters could discriminate between subjects who responded to SCV-07 and those who did not. Microarrays were done using peripheral blood RNA obtained at screening and on the last day of radiation from 28 subjects
doi:10.1016/j.oraloncology.2011.07.006
pmid:21824803
fatcat:hqep5wzccng5rlhqdn27vxdsti