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Synthesis of Quaternary -Amino Esters: A Remarkably Broad Substrate Scope in Aza-Friedel−Crafts Alkylation
[post]
2020
unpublished
Preserved Fulltext
A versatile synthetic protocol of aza-Friedel−Crafts alkylation has been developed for the synthesis of quaternary a-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/BrØnsted acid pair
doi:10.26434/chemrxiv.12111309
fatcat:s4jgizwr3vhibflqvafupyvg7a