Biomarker approaches in major depressive disorder evaluated in the context of current hypotheses

Mike C Jentsch, Erin M Van Buel, Fokko J Bosker, Anatoliy V Gladkevich, Hans C Klein, Richard C Oude Voshaar, Henricus G Ruhé, Uli LM Eisel, Robert A Schoevers
2015 Biomarkers in Medicine  
Major depressive disorder is a heterogeneous disorder, mostly diagnosed on the basis of symptomatic criteria alone. It would be of great help when specific biomarkers for various subtypes and symptom clusters of depression become available to assist in diagnosis and subtyping of depression, and to enable monitoring and prognosis of treatment response. However, currently known biomarkers do not reach sufficient sensitivity and specificity, and often the relation to underlying pathophysiology is
more » ... nclear. In this review, we evaluate various biomarker approaches in terms of scientific merit and clinical applicability. Finally we discuss how combined biomarker approaches in both preclinical and clinical studies can help to make the connection between the clinical manifestations of depression and the underlying pathophysiology. 21 2. Biomarker approaches in MDD
doi:10.2217/bmm.14.114 pmid:25731213 fatcat:qxlrzrfo6new7lyh6iu46dkun4