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Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis
AbstractIdiopathic pulmonary fibrosis is a fatal, incurable lung disease in which the intricate alveolar network of the human lung is progressively replaced by fibrotic scars, eventually leading to respiratory failure. Myofibroblasts are the effector cells that lead to abnormal deposition of extracellular matrix proteins and therefore mediate fibrotic disease not only in the lung but also in other organs. Emerging literature suggests a correlation between fibrosis and metabolic alterations indoi:10.1101/401265 fatcat:me5cgs6f5rbb5p4cbohdxnbzpm