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Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR
Journal of Biological Chemistry
The forkhead rhabdomyosarcoma transcription factor (FKHR) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor-binding protein-1 (IGF-BP-1) promoter and mediates insulin inhibition of IGF-BP-1 promoter activity. Cotransfection of mouse FKHR increased IGFBP-1 promoter activity 2-3-fold in H4IIE rat hepatoma cells; insulin inhibited FKHR-stimulated promoter activity ϳ70%. A C-terminal fragment of mouse FKHR (residuesdoi:10.1074/jbc.275.10.7289 pmid:10702299 fatcat:zk4leyrtt5b37ojtqw2yxr6kha