Experience of Superselective Intraarterial Chemotherapy in Head and Neck Cancers

Kensaku Hasegawa, Yuko Yamamoto, Takema Sakota, Hiromi Takeuchi, Hideyuki Kataoka, Eiji Takeuchi, Eiken Matsuda, Yasufumi Ohuchi, Toshio Kaminou, Hiroaki Nakatani, Taizo Takeda, Hiroya Kitano
2004 Practica Oto-Rhino-Laryngologica  
Internal-arterial chemotherapy was performed in 13 patients with head and neck cancers. We used a retrograde catheter to infuse antineoplastic agents. The tip of the catheter was led selectively into the main feeding artery of the tumor via superficial temporal artery and/or occipital artery. In this study, 4 cases had undergone operational procedures after chemotherapy with or without conventional externalbeam radiotherapy and 8 cases were treated with chemoradiotherapy alone. The other 1 case
more » ... received chemoradiotherapy after a non-curative operation. In this study, 11 of the 13 patients completed all therapeutic regimens. The median duration of follow-up was 23.6 months and there was no apparent reccurence in 9 (81.2%) of the 11 patients. One patient died of disease and 1 patient remained alive with disease. There were 10 events of under grade II toxicity and 2 patients died in the following period (grade V). These results demonstrate that, if the indications are appropriate, internal-arterial chemoradiotherapy is effective, with confirmed organ preservation in patients with head and neck cancers.
doi:10.5631/jibirin.97.147 fatcat:su43qy3fizhuhhrxsupawjfbe4