Internal-arterial chemotherapy was performed in 13 patients with head and neck cancers. We used a retrograde catheter to infuse antineoplastic agents. The tip of the catheter was led selectively into the main feeding artery of the tumor via superficial temporal artery and/or occipital artery. In this study, 4 cases had undergone operational procedures after chemotherapy with or without conventional externalbeam radiotherapy and 8 cases were treated with chemoradiotherapy alone. The other 1 case

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... received chemoradiotherapy after a non-curative operation. In this study, 11 of the 13 patients completed all therapeutic regimens. The median duration of follow-up was 23.6 months and there was no apparent reccurence in 9 (81.2%) of the 11 patients. One patient died of disease and 1 patient remained alive with disease. There were 10 events of under grade II toxicity and 2 patients died in the following period (grade V). These results demonstrate that, if the indications are appropriate, internal-arterial chemoradiotherapy is effective, with confirmed organ preservation in patients with head and neck cancers.