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A Defect in Coenzyme Q Biosynthesis Is Responsible for the Respiratory Deficiency inSaccharomyces cerevisiae abc1Mutants
Journal of Biological Chemistry
Ubiquinone (coenzyme Q or Q) is an essential component of the mitochondrial respiratory chain in eukaryotic cells. There are eight complementation groups of Q-deficient Saccharomyces cerevisiae mutants designated coq1-coq8. Here we report that COQ8 is ABC1 (for Activity of bc 1 complex), which was originally isolated as a multicopy suppressor of a cytochrome b mRNA translation defect (Bousquet, I., Dujardin, G., and Slonimski, P. P. (1991) EMBO J. 10, 2023-2031). Previous studies of abc1doi:10.1074/jbc.m100952200 pmid:11279158 fatcat:pvtdz62bsjhqlcgh4c6pgjzzfm