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Objective-To investigate cardiac function in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and clarify the clinical features of cardiomyopathy in MELAS. Patients-11 consecutive patients with MELAS (mean age at initial examination 11.3 years, range 4 to 16 years) were enrolled in the study. Six were followed for more than five years. Results-On echocardiographic examination, three patients showed increased left ventricular end diastolicdoi:10.1136/hrt.80.3.292 fatcat:t3hjxqyswjfvrg3sg5uukcweo4