Cross-reactivity with Diagnostic Products Corporation (DPC) amphetamine and methamphetamine radlolmmunoassay (RIA) reagents was determined for amphetamine, methamphetsmine, and a number of amphetamine analogs. Concentrations from 100 to 100,000 ng/mL were assayed. 3,4-Methylenedloxyamphetamlne (MDA) and 3,4-methylenedioxymethamphetmalne (MDMA) showed significant cross-reactivity for the amphetamine and methamphetamlne reagents respectively. 4-Hydroxymethamphetamine,

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... amlne (MDEA), and N,N-dimethyI-MDA also showed significant cross-reactivity with the methamphetamine reagents, but less than MDMA. None of the other analogs showed a positive result with the amphetamine or methamphetamine reagents at even the highest concentration, although several did show measurable crossreactivity. The L isomers of amphetamine and methamphetamine showed substantially less cross-reactivity than the n forms to which the respective antibody systems are targeted.