Effects of cisapride on the secretion of pancreatic polypeptide in healthy volunteers

AKIHIRO FUNAKOSHI, HIROTSUGU SHINOZAKI, KAZUNORI MIYAZAKI, ITSURO NAKANO, HIROSHI IBAYASHI
1986 Tohoku journal of experimental medicine  
Plasma human pancreatic polypeptide (hPP) responses to intravenous injections of a new gastric and intestinal motility promoting agent. R51 619 (cisapride), were studied in healthy volunteers. The mean fasting concentrations of plasma hPP (39+5.4 pg/ml ; mean± SE.) were elevated significantly to the peak values of 118+25.1 pg/ml 30 min after the drug had been given in a dose of 4 mg over 5 min. However, plasma insulin (IRI), glucose and prolactin levels were not elevated. Atropine diminished
more » ... opine diminished the cisapride-induced hPP elevation, thereby suggesting that cisapride induced release of acetylcholine but had no antidopaminergic action.
doi:10.1620/tjem.150.155 pmid:3544336 fatcat:vyivjdtwtvezpeg7a5cd5xefda