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Phosphorus Dendrimers as Carriers of siRNA—Characterisation of Dendriplexes
2013
Molecules
There are many types of dendrimers used as nanomolecules for gene delivery but there is still an ongoing search for ones that are able to effectively deliver drugs to cells. The possibility of gene silencing using siRNA gives hope for effective treatment of numerous diseases. The aim of this work was to investigate in vitro biophysical properties of dendriplexes formed by siRNA and cationic phosphorus dendrimers of 3rd and 4th generation. First, using the ethidium bromide intercalation method,
doi:10.3390/molecules18044451
pmid:23591925
fatcat:57wgsu3yvbgdni6hmgrmratlle