The COVID-19 severity is usually correlated to age, gender, obesity, and other comorbidities. Nevertheless, with the advance of the vaccination, the number of people infected with SARS-COV-2 is decreasing. On the other hand, children infection is becoming more recurrent, while having milder symptoms. One can argue that the child's innate immunity, trained by live vaccines and frequent infections, is more effective to control the infection. Besides, the COVID-19 development in children is

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... ted with hyper inflammatory condition, the Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this review is to overview the immunological aspects of COVID-19 in children and to discuss aspects related to vaccination protocols for children and their relevance to the control of the pandemic.