Research progress of pharmacogenetics with wet age-related macular degeneration

Si-Meng Zheng, Lu Zhang
2020 Guoji Yanke Zazhi  
Age-related macular degeneration(ARMD)is a multifactorial disease, genetic factors play important roles in the pathogenesis of the disease. To date, intraocular injection of anti-vascular endothelial growth factor drugs is the first choice for the treatment of wet ARMD, but the response is variable. This review summarizes vascular endothelial growth factor(VEGF)gene, complement factor H(CFH)gene, age-related maculopathy susceptibility 2(ARMS2)gene and high-temperature requirement A-1(HTRA1)gene
more » ... ment A-1(HTRA1)gene single-nucleotide polymorphisms(SNP)in the study of pharmacological genetics of wet ARMD. It is still worthy of further investigations that the genetic mechanism of the disease, so that we can provide individualized treatment sequences and predict the response to anti-VEGF therapy.
doi:10.3980/j.issn.1672-5123.2020.1.16 doaj:6c97ea4d47134d178c6e716cd807d91d fatcat:vv2th33l2rajxa2wnqo3fqwmhq