ENHANCED ANTIPYRETIC ACTIVITY OF NEW 2,5-SUBSTITUTED 1,3,4-OXADIAZOLES ENCAPSULATED IN ALGINATE/GELATIN PARTICULATED SYSTEMS

Corina Cheptea, V Şunel, Mihaela Holban, J Desbrières, M Popa, Cătălina Lionte
2012 CELLULOSE CHEMISTRY AND TECHNOLOGY Cellulose Chem. Technol   unpublished
New 1,3,4-oxadiazoles with pharmacological potential, derived from 5-nitroindazole, have been synthesized. Their chemical structure has been established by elemental and spectral analyses (FT-IR and 1 H-NMR). The oxadiazoles presented low toxicity, one compound, either in a free form or loaded in polymeric microcapsules, also showing a remarkable antipyretic activity, similar to that of acetylsalicylic acid.
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