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Plasmin Plays a Role in the In Vitro Generation of the Linear IgA Dermatosis Antigen LADB97
2009
Journal of Investigative Dermatology
Collagen XVII (BP180) and its shed ectodomain represent major autoantigens in dermatoses of the pemphigoid group. The 120 kDa ectodomain is constitutively shed from the cell surface by disintegrin-metalloproteinases (ADAMs). Part of it is further processed to a 97 kDa fragment (LABD97), an autoantigen in linear IgA dermatosis (LAD), but the responsible proteinases remain elusive. In this study, we identified the 120 and the 97 kDa ectodomain in blister fluids of bullous pemphigoid patients
doi:10.1038/jid.2008.424
pmid:19158842
fatcat:25xbm4ifpbbf3ii6ur2ba2rqf4