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Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
2006
Nucleic Acids Research
Correct orthology assignment is a critical prerequisite of numerous comparative genomics procedures, such as function prediction, construction of phylogenetic species trees and genome rearrangement analysis. We present an algorithm for the detection of non-orthologs that arise by mistake in current orthology classification methods based on genome-specific best hits, such as the COGs database. The algorithm works with pairwise distance estimates, rather than computationally expensive and
doi:10.1093/nar/gkl433
pmid:16835308
pmcid:PMC1500873
fatcat:b4lvrifrbveujajwq4r5wzm33q