FEASIBILITY OF ASSAM BORA RICE BASED MATRIX MICRODEVICES FOR CONTROLLED RELEASE OF WATER INSOLUBLE DRUG

Nikhil Sachan, A Bhattacharya
unpublished
The present investigation proposed and examined the Bora rice of Assam in formulation of controlled release drug delivery systems being utilized as a natural mucoadhesive matrixing agent for modulation of drug release. The Bora rice is a festival food in Assam and is characterized by its dull milky appearance having composed of mainly amylopectin and traces of amylase; it is also known as waxy or sticky rice. In this phase of project, the controlled release microparticulate drug delivery
more » ... were fabricated using Bora rice backbone along with sodium alginate and a model medicament to evaluate the potential of polymer backbone in modulation of drug release behaviour and to find out the kinetics of drug release from formulated matrix devices. The formulated drug delivery systems were characterized for particle size and size distribution, surface characteristics using SEM, drug excipient compatibility study using UV, FTIR, and DSC. The in vitro release of Ibuprofen was studied in USP XXIV Dissolution test apparatus (basket type). The in vitro dissolution profile studies for characterization of release kinetics were carried as per the guidelines provided by the Center for Drug Evaluation and research FDA for modified release dosage forms. The experimental observations have shown promising results for the pharmaceutical utility of Assam Bora rice as excipient in formulation of mucoadhesive controlled drug delivery systems.
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