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Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture
1989
Cancer Research
The development of the oxazaphosphorine cytostatics cyclophosphamide, ifosfamide, and trofosfamide was based on the idea of applying the transport form/active form principle to the highly reactive nitrogen mustard group. A critical analysis and synopsis of the available results and knowledge will include examination of the extent to which the hypotheses on which this concept is based have been confirmed by experimental and clinical findings: 1. Chemical synthesis succeeded in converting the
pmid:2491747
fatcat:dlbgd37fnvgcdcxmxyqs34dkdi