Seronegative lupus membranous nephropathy

Mandya Chikkalingaiah Kiran
2016 International Journal of Case Reports and Images  
International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties. Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. ABSTRACT Introduction:
more » ... Lupus nephritis represents the greater part of systemic lupus erythematosus (SLE) involvement. Antinuclear antibody (ANA) is positive in more than 95% of SLE population. Literature depicts the prevalence of ANA negativity around 1-5% and more prevalent in young females as seropositive lupus. Existence of full-house nephropathy is generally associated with lupus nephritis. Case Report: We present a case of full-house nephropathy in a 24-year-old female patient with negative serology for SLE presenting with nephrotic syndrome. Renal biopsy revealed tubuloreticular inclusions (TRIs) in endothelial cells differentiating itself from rarer C1q nephropathy. Patient had partial response with conventional immunotherapy with mycophenolate mofetil (MMF) and prednisone. Conclusion: The role of B cell depleting therapy in seronegative lupus; this population needs to be explored in future. ABSTRACT Introduction: Lupus nephritis represents the greater part of systemic lupus erythematosus (SLE) involvement. Antinuclear antibody (ANA) is positive in more than 95% of SLE population. Literature depicts the prevalence of ANA negativity around 1-5% and more prevalent in young females as seropositive lupus. Existence of full-house nephropathy is generally associated with lupus nephritis. Case Report: We present a case of full-house nephropathy in a 24-yearold female patient with negative serology for SLE presenting with nephrotic syndrome. Renal biopsy revealed tubuloreticular inclusions (TRIs) in endothelial cells differentiating itself from rarer C1q nephropathy. Patient had partial response with conventional immunotherapy with mycophenolate mofetil (MMF) and prednisone. Conclusion: The role of B cell depleting therapy in seronegative lupus; this population needs to be explored in future.
doi:10.5348/ijcri-2016110-cr-10698 fatcat:33g5e5nxbzb5jffomrogpavrf4