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Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1
The Phospholipase A2 Receptor 1 (PLA2R1) was first identified for its ability to bind some secreted PLA2s (sPLA2s). It belongs to the C-type lectin superfamily and it binds different types of proteins. It is likely a multifunctional protein that plays a role i) in inflammation and inflammatory diseases, ii) in cellular senescence, a mechanism participating in aging and age-related diseases including cancer, and iii) in membranous nephropathy (MN), a rare autoimmune kidney disease where PLA2R1doi:10.1038/s41598-020-64863-y pmid:32424163 fatcat:wuja2ftyu5gazaqiffxxvybxgi