Non-alcoholic Steatohepatitis—An Endocrine Disorder

Bogdan Balas, Rafeeq Ali, Kenneth Cusi
2007 US Endocrinology  
Non-alcoholic Steatohepatitis Non-alcoholic fatty liver disease (NAFLD) is a chronic liver condition frequently associated with type 2 diabetes and characterized by insulin resistance and hepatic fat accumulation. Liver fat may range from simple steatosis to severe steatohepatitis with necroinflammation and variable degrees of fibrosis (non-alcoholic steatohepatitis (NASH)). About 40% of patients with NAFLD develop NASH, with an early study reporting progression to fibrosis and/or cirrhosis in
more » ... nd/or cirrhosis in 15-20% of NASH. 1 More recent series have shown that this figure may be much higher, ranging from 32 to 41%. 2 Moreover, very recent evidence suggests that the lifespan of patients with NAFLD is not only significantly shortened by liver-related morbidity, but also by a higher incidence of cardiovascular disease. 3, 4 Thus, substantial benefit may be expected from improving current screening strategies, early detection, and finding potential treatments of NAFLD.
doi:10.17925/use.2007.00.2.79 fatcat:y6amujayufejvde4wy56w7tsnm