Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

Emin Ozlu, Ayse Serap Karadag, Aybala E. Toprak, Tugba K. Uzuncakmak, Fethullah Gerin, Feyza Aksu, Ozlem Ozakpınar, Necmettin Akdeniz
2016 Dermatology  
platelet volume than the healthy controls (p < 0.05). Conclusions: Serum endocan levels did not change significantly in patients with LP, and there were significant differences in haematological and biochemical parameters. Introduction Lichen planus (LP) is a chronic inflammatory disease that affects the skin and mucous membranes [1] . Although its aetiology and pathogenesis are not fully understood, LP is believed to be a T-cell-mediated inflammatory disease. The 6 Ps of LP are planar
more » ... ped), purple, polygonal, pruritic, papules, and plaques. It is clinically characterized with violet-coloured, flat, polygonal papules or plaques on the ankles, thighs, abdomen, and extremities [2] . Inflammation can cause lipid metabolism disorders such as increases in low-density lipoprotein cholesterol and triglyceride levels, and decreases in high-density lipoprotein cholesterol levels [3] . It is a known fact that Abstract Background and Objective: The current study aimed to evaluate cardiovascular risk factors, haematological and biochemical parameters, and serum endocan concentrations in lichen planus (LP) patients. Methods: This study was conducted with 86 cases, including 43 LP patients and 43 healthy controls. Cardiovascular risk factors, haematological and biochemical parameters, and endocan levels were evaluated. Results: The serum endocan concentrations of LP patients were not significantly different from those of the healthy controls (p > 0.05). There were no significant differences in the serum endocan levels according to classification by cardiovascular risk factors and smoking history (p > 0.05). In the LP group, white blood cell count, platelet distribution width and monocyte count/high-density lipoprotein cholesterol ratios were significantly higher when compared to the healthy controls (p < 0.05). The LP group had a lower mean
doi:10.1159/000447587 pmid:27508489 fatcat:lii4tijeu5gchdzhyjmq52mqcm