P412 Effect of post-infarction changes of heart on autoregulation of cerebral circulation and manifestation of seizure activity M. Mamalyga Bakoulev Center for Cardiovascular Surgery RAMS, Moscow, Russian Federation Purpose: To study the specifics of changes in autoregulation of cerebral hemodynamic in different periods past the myocardial infarction and its connection to seizure activity. Methods: The tests were performed on white male Wistar rats. Myocardial infarction (IM) was modeled by

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... tion of left coronary artery. Record of video ECG-EEG was performed in on line mode using telemetry system by ADInstruments (Australia). Transmitter (TR40BB) was implanted in the abdominal cavity of the rat. Ultrasound study controlled cardiac output, volumetric blood flow in common carotid artery, linear blood flow (LBF) in basilar artery. Autoregulation of cerebral hemodynamic was performed using hypercapnic and compression functional test. Seizure activity of the animals was detected using the EEG changes in rhythmic photostimulation. Magnetic resonance tomography was performed using "Bruker Biospec 70/30".