Increased developed of colorectal tumor may be linked with Helicobacter pylori. However, the underlying mechanisms were still uncertain. objective: Helicobacter pylori infection in the world, in particular in developing countries, is one of most common chronic bacterial infections, This bacterium is responsible for many diseases such as gastritis, peptic ulcer, lymphoma and in some patients may lead to gastric cancer, it is in the world has known 2nd major cause of death from cancer. H.pylori

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... fection may likely raise the risk of colorectal cancer, according to recently published studies. The aimed of this study to detected the role of H. pylori in colorectal cancer. Methods: Serum of 50 colorectal cancer and colorectal normal with positive H. pylori infection patients were estimated by 14Urea breath test and 25 subjects with no any inflammatory disease as the control group. from each patient were collected Blood samples to investigated of H. pylori specific immunoglobulin G (IgG) and CagA IgG antibodies by using enzyme-linked immunosorbent assay (ELISA). Results: A total of 50 patients in this study 25 had colorectal cancer and 25 had colorectal normal with H. pylori infection (immunoglobulin G (IgG) P ˂ 0.01 and CagA IgG antibodies P < 0.01) were significantly more prevalent in the patients with colorectal_ cancer and colorectal normal with Helicobacter pylori _infection compared with the healthy controls (P= 0.00019, P= 0.00022 respectively) The relation was statistically non-significant between the antibody seropositivity and gender but Highly significant with age. Conclusion: The findings indicate that Helicobacter pylori_ infection can be regarded as a contributing influence for progressive tumor in colorectal.