The antimicrobial agents and vaccines are playing a critical role in fighting infectious diseases. The impact of both the vaccines and antimicrobial agents has been phenomenal across the globe in reducing mortality and morbidity rate, thus being hailed as the greatest accomplishments of modern medicine. Both the vaccines and the antimicrobial agents commonly known as the antibiotic act against causative agents of the infectious disease in different ways. The antimicrobial agents are therapeutic

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... tools while the vaccines are the preventive tools thus the latter is more of benefits since the prevention is better than the cure. Antibiotics are short acting tools while the vaccines have the long term impact and memory. The combination of these tools are beneficial in containing and fighting antimicrobial drug resistances incidences. Antimicrobial resistance is one of the major challenge of the public health globally, many people dies everyday due to antimicrobial resistance which is based on the two major mechanism that is the survival instinct of bacteria and indiscriminate use of antibiotics. The survival tactic of the bacteria generates several mechanism in bacteria that conferred resistance to the antimicrobial agents. This may also happen rapidly and cumulatively giving rise to multi- antibiotic resistance variance. The study paper aimed to identify antimicrobial resistance, its public health implications and the role played by vaccines in reducing antimicrobial resistance. It was noted that vaccines play a critical role in reducing the impact of the antimicrobial resistance thus the appropriate use of the vaccines has successfully demonstrated the reduction incidences of antimicrobial resistance, however, Multidisciplinary approach is required for progressive alternative strategies including probiotics, antibodies, and vaccines that have shown promising results in trials that suggest the role of these alternatives as preventive or adjunct therapies in future.