A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold

Richard J. Spears, Cliona McMahon, Monika Shamsabadi, Calise Bahou, Ioanna Thanasi, Lea Rochet, Nafsika Forte, Fabien Thoreau, James Baker, Vijay Chudasama
2021 Chemical Communications  
Herein we report a thiol-labile cysteine protecting group based on an unsaturated pyridazinedione (PD) scaffold. We establish compatibility of the PD in conventional solid phase peptide synthesis (SPPS), showcasing this...
doi:10.1039/d1cc03802h pmid:34747956 fatcat:z37ufmuejfcgbcz7iz5pvy3xga