Imidazole is a heterocyclic compound with five membered unsaturated ring structure composed of 3 carbons and 2 nitrogen atoms at non-adjacent positions. Imidazole drugs have broad applications in many areas of clinical medicine. These are currently used as tools in pharmacological studies. The important therapeutic properties of imidazole related drugs have encouraged the medicinal chemists to synthesize and test a large number of novel molecules. In this investigation, it was of interest to

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... thesize 1-(2-bromophenyl)-2-phenyl-1H-phenanthro[9,10-d]imidazole, by reaction of substituted imidazole with bromine in the presence of acetic acid. Various derivatives i.e. 1-(2-bromophenyl)-2-phenyl-1H-phenanthro[9,10-d]imidazole, 1-(2-bromophenyl)-2-(2-nitrophenyl)-1H-phenanthro [9,10-d]imidazole, 1-(2-bromophenyl)-2-(4-chlorophenyl)-1H-phenanthro [9,10-d]imidazole, 1-(2-bromophenyl)-2-(4-styryl-phenyl)-1H-phenanthro [9,10-d]imidazole and 1-(2-bromophenyl)-2-(4-styryl-phenyl)-1H-phenanthro [9,10-d]imidazole were formed with respective yield of 74, 64, 73, 79 and 72%. The structures of the compounds have been established on the basis of spectral analytical data. All the derivatives have been screened for their antimicrobial activities at the 100µg/ml and 200µg/ml against Candida albicans.