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Cell-based quantification of molecular biomarkers in histopathology specimens
2011
Histopathology
Aims-To investigate the use of a computer-assisted technology for objective, cell-based quantification of molecular biomarkers in specified cell types in histopathology specimens, with the aim of advancing current visual estimation or pixel-level (rather than cell-based) quantification methods. Methods and results-Tissue specimens were multiplex-immunostained to reveal cell structures, cell type markers, and analytes, and imaged with multispectral microscopy. The image data were processed with
doi:10.1111/j.1365-2559.2011.03878.x
pmid:21771025
pmcid:PMC3142095
fatcat:6ypdqxab7nctzbs7pe5neq6u7i